Clonic seizures in GAERS Rats after oral administration of enrofloxacin

SH Bauquier; JL Jiang; A Lai; MJ Cook

Journal article

Clonic seizures in GAERS Rats after oral administration of enrofloxacin

SH Bauquier, JL Jiang, A Lai, MJ Cook

Comparative Medicine | AMER ASSOC LABORATORY ANIMAL SCIENCE | Published : 2016

Abstract

The aim of this study was to evaluate the effect of oral enrofloxacin on the epileptic status of Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Five adult female GAERS rats, with implanted extradural electrodes for EEG monitoring, were declared free of clonic seizures after an 8-wk observation period. Enrofloxacin was then added to their drinking water (42.5 mg in 750 mL), and rats were observed for another 3 days. The number of spike- And-wave discharges and mean duration of a single discharge did not differ before and after treatment, but 2 of the 5 rats developed clonic seizures after treatment. Enrofloxacin should be used with caution in GAERS rats because it might induce clonic ..

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University of Melbourne Researchers

Sebastien Bauquier Author

Alan Lai Author

Mark Cook Author

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Grants

Awarded by NHMRC

Awarded by Australian Research Council (ARC)

Awarded by Australian Research Council

Funding Acknowledgements

We gratefully acknowledge the sponsorship of the Victorian Government through its Science Technology and Innovation Initiative, administered by the Department of Industry, Innovation, and Regional Development, and of NHMRC (grant no. 619614). We thank the Australian Research Council (ARC) for continuing financial support (ARC grant no. DP0987344).